Renny Pacheco-Calderón

Prenatal exposure to ketamine in rats: Implications on animal models of schizophrenia.

Developmental Psychobiology January 2018 Carlos Coronel-Oliveros, Renny Pacheco-Calderón

Schizophrenia is a complex neuropsychiatric disorder characterized by hallucinations, delusions, anhedonia, flat affect and cognitive impairments. The aim of this study was to propose a prenatal treatment with ketamine, a psychedelic drug that acts as a non-competitive inhibitor of glutamate NMDA receptors, as a neurodevelopmental animal model of schizophrenia. The drug was applied (i.m. 60...