Nature Communications
May 5, 2026
T Lyons, M Spriggs, L Kerkelä et al.
19 citations
Psychedelics have robust effects on acute brain function and long-term behavior but whether they also cause enduring functional and anatomical brain changes is largely unknown. In an exploratory, placebo-controlled, within-subjects, electroencephalography (EEG), and magnetic resonance imaging (MRI) study in 28 healthy, entirely psychedelic-naive participants, anatomical and functional brain...
International review of neurobiology
2025
A M Wingert, Claudio Agnorelli, Joseph Peill et al.
1 citation
Depressive disorders continue to pose a major clinical challenge worldwide, particularly given the high prevalence and increasing number of treatment-resistant cases. Over the past decade, advances in research have elucidated the antidepressant potential of psilocybin and other 5-HT₂A receptor agonists in patients with major depressive disorder (MDD) and treatment-resistant depression (TRD)....
Current Topics in Behavioral Neurosciences
2024
D J Nutt, Joseph Peill, B Weiss et al.
30 citations
Psychedelic drugs such as psilocybin and ketamine are returning to clinical research and intervention across several disorders including the treatment of depression. This chapter focusses on psychedelics that specifically target the 5-HT2A receptor such as psilocybin and DMT. These produce plasma-concentration related psychological effects such as hallucinations and out of body experiences,...
Journal of Psychopharmacology
August 31, 2017
R L Carhart-Harris, D J Nutt
Previous attempts to identify a unified theory of brain serotonin function have largely failed to achieve consensus. In this present synthesis, we integrate previous perspectives with new and older data to create a novel bipartite model centred on the view that serotonin neurotransmission enhances two distinct adaptive responses to adversity, mediated in large part by its two most prevalent and...
Psychopharmacology
October 2015
Mendel Kaelen, Frederick S. Barrett, Leor Roseman et al.
There is renewed interest in the therapeutic potential of psychedelic drugs such as lysergic acid diethylamide (LSD). LSD was used extensively in the 1950s and 1960s as an adjunct in psychotherapy, reportedly enhancing emotionality. Music is an effective tool to evoke and study emotion and is considered an important element in psychedelic-assisted psychotherapy; however, the hypothesis that...
Psychopharmacology
February 2015
R L Carhart-Harris, Mendel Kaelen, M G Whalley et al.
Lysergic acid diethylamide (LSD) has a history of use as a psychotherapeutic aid in the treatment of mood disorders and addiction, and it was also explored as an enhancer of mind control. The present study sought to test the effect of LSD on suggestibility in a modern research study. Ten healthy volunteers were administered with intravenous (i.v.) LSD (40-80 μg) in a within-subject...
Drug and Alcohol Dependence
October 1, 2011
R L Carhart-Harris, L A King, D J Nutt
This study sought to collect information on the former legal-high 'mephedrone' using a web-based survey targeted at mephedrone users. The survey was advertised on websites frequented by drug users. Individuals were invited to complete the survey if they had taken mephedrone on at least one occasion in the past. One thousand and six completed forms were received from declared users, making this...