Ketamine therapy is effective in alleviating symptoms of psychiatric disorders such as depression and anxiety; however, its increasing recreational use raises concerns about potential abuse. Hericium erinaceus mycelium, which contains the bioactive compound erinacine A, has shown promise in promoting brain health. This study investigated whether H. erinaceus mycelium and erinacine A could...
N-acetylcysteine (NAC) has been reported to reverse the psychotomimetic effects in the rodent phencyclidine model of psychosis and shown beneficial effects in treating patients with schizophrenia. The effect of NAC has been associated with facilitating the activity of cystine-glutamate antiporters on glial cells concomitant with the release of non-vesicular glutamate, which mainly stimulates...
The repeated administration of methamphetamine (MA) to animals in a single-day 'binge' dosing regimen produces damage to dopamine and serotonin terminals and psychosis-like behaviours similar to those observed in MA abusers. The present study aimed to examine the effects of MA binge exposure on 5-HT2A receptors, the subtype of serotonin receptors putatively involved in psychosis. ICR male mice...