Zaburzenia depresyjne są jednymi z najczęściej występujących chorób psychicznych na świecie. Leczenie depresji stanowi ważny problem medyczny, a strategie farmakologiczne oparte na wyrównywaniu zaburzeń transmisji monoaminergicznych w mózgu wiążą się z opóźnionym w czasie efektem przeciwdepresyjnym. Ponadto, coraz większy odsetek pacjentów cierpi na depresję lekooporną, gdzie pomimo wdrożenia...
Recently, a new class of psychedelic compounds named NBOMe (or 25X-NBOMe) has appeared on the illegal drug market. NBOMes are analogs of the 2C family of phenethylamine drugs, originally synthesized by Alexander Shulgin, that contain a N-(2-methoxy)benzyl substituent. The most frequently reported drugs from this group are 25I-NBOMe, 25B-NBOMe, and 25C-NBOMe. NBOMe compounds are ultrapotent and...
The last decade has seen a rapid and continuous growth in the availability and use of novel psychoactive substances (NPS) across the world. Although various products are labeled with warnings "not for human consumption", they are intended to mimic psychoactive effects of illicit drugs of abuse. Once some compounds become regulated, new analogues appear in order to satisfy consumers' demands and...
Methoxetamine is one of the constantly growing group of novel psychoactive substances that has emerged in recent years. The compound belongs to the arylcyclohexylamine class, which is used for its recreational and psychedelic effects. Methoxetamine is a structural analogue of ketamine, with a much longer duration of action and intensity of effects, and has been extensively advertised as its...
Salvia divinorum is a sage endemic to a small region of Mexico and has been traditionally used by the Mazatec Indians for divination and spiritual healing. Recently, it has gained increased popularity as a recreational drug, used by adolescents and young adults as an alternative to marijuana and LSD. Salvinorin A, the major active ingredient of the plant, is considered to be the most potent...
Recently, a new class of “designer drugs” has emerged on the drug use market, known as “legal highs” or “herbal highs”. They include a wide range of products, from natural plant-originated substances to synthetic compounds, that can be purchased both online and from high street retailers. “Legal highs” mimic psychoactive effects of illicit drugs of abuse. However, they are claimed to consist of...