Psychedelic MedicineOctober 21, 2026Michael D. Masucci, Alex S. Cohen, Christopher R. Cox et al.
Background: Within the last decade, ayahuasca, a brew containing a serotonin 2A receptor agonist (i.e., a classical psychedelic compound), has received increased attention as a possible intervention for posttraumatic stress disorder. Ayahuasca has demonstrated potential for long-term symptom reduction, but the biobehavioral changes caused by ayahuasca have not been defined quantitatively or...
ABSTRACT Posttraumatic stress disorder (PTSD) is a mental health condition that can develop following exposure to a traumatic event, often with persistent anxiety and depressive symptoms. Recent research suggests the microbiome-gut-brain axis may play an important role in the etiology and pathophysiology of PTSD. At the same time, retreats incorporating psychedelic-assisted therapies have...
Abstract Background Studies have shown evidence for long-term effects of psychedelics on personality, but comprehensive models of psychedelic-mediated personality changes have yet to be explored. Aims The present study aims to investigate (1) perceptions of personality change in the general population, (2) moderators of perceived personality change including setting and drug type, and (3)...
Background: Evidence suggests that psychedelic-assisted therapy carries transdiagnostic efficacy in the treatment of mental health conditions characterized by low mood and the use of avoidance coping strategies. Aims: While preliminary evidence suggests that psychological flexibility and emotion regulation processes play an important role within psychedelic therapy, this prospective study...
Abstract The present study examines the association between the ceremonial use of ayahuasca – a decoction combining the Banistereopsis caapi vine and N,N Dimethyltryptamine-containing plants – and changes in personality traits as conceived by the Five-Factor model (FFM); as well as the degree to which demographic characteristics, baseline personality, and acute post-ayahuasca experiences affect...