Psychedelic compounds found in Psilocybe mushrooms are being studied for treating central nervous system disorders, but obtaining enough pure material from fungi for research is challenging. This review examines synthetic chemistry methods to produce these molecules, covering classic historical syntheses, modern metal-catalyzed coupling reactions, and biocatalytic approaches. The authors note that alternative synthetic routes will likely be needed as therapeutic interest in these compounds grows.
Alcohol use disorder involves excessive drinking, and existing medications often fail to prevent relapse. Psilocybin is being studied as a treatment for substance use disorders. This review of recent clinical trials finds that psilocybin appears to reduce craving for alcohol, but its effect on overall alcohol consumption is less clear. The authors note that future trials would benefit from larger sample sizes and standardized tests.
Alcohol use disorder involves excessive drinking, and current medications often do not prevent relapse. Psilocybin is being studied for treating substance use disorders. This review of recent clinical trials finds that psilocybin appears to reduce craving, but its effect on overall alcohol consumption is less clear. Future trials would benefit from larger sample sizes and standardized tests.