Modulating glutamatergic neurotransmission induces alterations in conscious experience that mimic the symptoms of early psychotic illness. We review studies that use intravenous administration of ketamine, focusing on interindividual variability in the profundity of the ketamine experience. We will consider this individual variability within a hypothetical model of brain and cognitive function...
We would like to report a case of Capgras syndrome in a healthy subject, which was induced by ketamine, [an antagonist of the N-methyl D-aspartate (NMDA) subtype of glutamate receptors]. We believe this is the first report of delusion-like misidentification following controlled administration of a psychotomimetic drug, raising the possibility that the neurochemical and cognitive mechanisms...
INTRODUCTION: Various experimental manipulations, usually involving drug administration, have been used to produce symptoms of psychosis in healthy volunteers. Different drugs produce both common and distinct symptoms. A challenge is to understand how apparently different manipulations can produce overlapping symptoms. We suggest that current Bayesian formulations of information processing in...
Background: The psychosis-inducing effect of ketamine is important evidence supporting the glutamate hypothesis of schizophrenia. However, the symptoms the drug produces have not been described systematically. Aim: To examine the effects of ketamine in healthy people using a structured psychiatric interview. Method: Ketamine (200 ng/ml) or placebo was administered by continuous infusion to 15...