Animal Models of Serotonergic Psychedelics
ACS Chemical Neuroscience September 24, 2012 James B. Hanks, Javier González-Maeso 152 citations
The serotonin 5-HT(2A) receptor is the major target of psychedelic drugs such as lysergic acid diethylamide (LSD), mescaline, and psilocybin. Serotonergic psychedelics induce profound effects on cognition, emotion, and sensory processing that often seem uniquely human. This raises questions about the validity of animal models of psychedelic drug action. Nonetheless, recent findings suggest...