Synthesis and bioactivity of psilocybin analogues containing a stable carbon–phosphorus bond
RSC Medicinal Chemistry January 1, 2024 Marthe Vandevelde, Andreas Simoens, Bavo Vandekerckhove et al. 4 citations
Psilocybin analogues containing a stable phosphorus-carbon bond were synthesized to test their activity at serotonin 5-HT2A, 5-HT2B, and TNAP receptors. The modified compounds were designed to resist hydrolysis, potentially altering their biological effects and receptor selectivity. The work describes the chemical synthesis and initial biological evaluation of these analogues.