Synthesis and bioactivity of psilocybin analogues containing a stable carbon–phosphorus bond
Marthe Vandevelde, Andreas Simoens, Bavo Vandekerckhove, Christian V. Stevens
RSC Medicinal Chemistry January 1, 2024 DOI: 10.1039/d4md00043a (opens in new tab) via OpenAlex
Summary
AI-generated from the abstractPsilocybin analogues containing a stable phosphorus-carbon bond were synthesized to test their activity at serotonin 5-HT2A, 5-HT2B, and TNAP receptors. The modified compounds were designed to resist hydrolysis, potentially altering their biological effects and receptor selectivity. The work describes the chemical synthesis and initial biological evaluation of these analogues.
Study at a glance
| Characteristics | Laboratory study Peer reviewed |
|---|---|
| Intervention | psilocybin analogues |
| Topics | Psilocybin |
| Keywords | Phosphorus Chemistry Carbon fibers |
| Citations | 4 |
| Key finding | Psilocybin analogues with a non-hydrolysable P–C bond were synthesized and evaluated for activity at 5-HT2A, 5-HT2B, and TNAP receptors. |
Abstract
Psilocybin analogues have been synthesized comprising a non-hydrolysable P–C bond to evaluate the biological activity and the selectivity towards 5-HT 2A R, 5-HT 2B R and the TNAP receptor.