Research published in RSC Medicinal Chemistry

Continuous flow synthesis of N,N-dimethyltryptamine (DMT) analogues with therapeutic potential.

RSC Medicinal Chemistry October 7, 2024 Andreas Simoens, Andreas Dejaegere, Marthe Vandevelde et al. 2 citations

Herein, we describe the continuous flow synthesis and in-line extraction of N,N-dimethyltryptamine (DMT) and several of its analogues using a Fischer indole reaction, along with a larger gram scale synthesis (4.75 g) of the model compound. These products could then be quickly transformed into their respective fumarate salts, making them easier to handle and stable for long time storage using a...

DOI: 10.1039/d4md00562g Full text Psychedelics Pharmaceutical manufacturing Mental health treatments Drug synthesis +1

Synthesis and bioactivity of psilocybin analogues containing a stable carbon–phosphorus bond

RSC Medicinal Chemistry 2024 Marthe Vandevelde, Andreas Simoens, Bavo Vandekerckhove et al. 4 citations

Psilocybin analogues have been synthesized comprising a non-hydrolysable P–C bond to evaluate the biological activity and the selectivity towards 5-HT 2A R, 5-HT 2B R and the TNAP receptor.

DOI: 10.1039/d4md00043a Psilocybin Phosphorus Carbon fibers

Papers

Continuous flow synthesis of N,N-dimethyltryptamine (DMT) analogues with therapeutic potential.

Synthesis and bioactivity of psilocybin analogues containing a stable carbon–phosphorus bond