Broadband Cortical Desynchronization Underlies the Human Psychedelic State
Journal of Neuroscience September 18, 2013 Matthew J. Brookes, David Errtizoe, Ben Sessa et al. 501 citations
Psychedelic drugs produce profound changes in consciousness, but the underlying neurobiological mechanisms for this remain unclear. Spontaneous and induced oscillatory activity was recorded in healthy human participants with magnetoencephalography after intravenous infusion of psilocybin—prodrug of the nonselective serotonin 2A receptor agonist and classic psychedelic psilocin. Psilocybin...