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Soraya Seedat

2 papers in the library · publishing 2025-2026

Papers

Efficacy of 3,4-methylenedioxymethamphetamine (MDMA)-assisted therapy for posttraumatic stress disorder: A systematic review and meta-analysis of clinical and functional outcomes

European Neuropsychopharmacology March 12, 2026 Natalia E. Fares-Otero, Yuki Furukawa, Marit Sijbrandij et al.

A systematic review and meta-analysis of randomized controlled trials found that MDMA-assisted therapy (MDMA-AT) was associated with reductions in PTSD symptom severity and dissociative symptoms, and may improve functioning, compared with control conditions. No clear benefit was observed for depressive symptoms. The analysis included 8 trials with 298 participants for the primary outcome. However, the overall certainty of the evidence was very low due to high risk of bias in outcome measurement, deviations from intended interventions, small sample sizes, and lack of active controls in most studies. Larger, higher-quality trials with active controls and long-term follow-up are needed to determine efficacy.

DOI: 10.1016/j.euroneuro.2026.112802 (opens in new tab) Dissociative Posttraumatic stress Clinical trial Cognition +14

Considerations for sociocultural adaptations of a mindfulness-based program within a low socioeconomic setting in Cape Town, South Africa

BMC Complementary Medicine and Therapies December 30, 2025 Sarah Foale, Soraya Seedat, Tanya Heyns

Stakeholders in Cape Town, South Africa agreed that mindfulness-based programs can be adapted to be feasible, acceptable, and accessible for participants in low socioeconomic settings. Key adaptations include strategies to encourage attendance and retention, program structure and content, trauma sensitivity, facilitator qualities and training, communication strategies, language use, and translation approaches. The findings suggest that appropriately and sensitively adapted programs may benefit participants in low-resource and high-risk trauma environments, though further research is needed on the specifics of how, where, and when to offer them.

DOI: 10.1186/s12906-025-05122-3 (opens in new tab) Full text (opens in new tab) Mindfulness Socioeconomic status Snowball sampling Attendance +10