The biogenic formation of certain methylated derivatives of catecholamines and serotonin have been discussed in causal connection with schizophrenia. Positive and negative results by various research groups in detecting 3,4-dimethoxyphenylethylamine (DMPEA) in urine of schizophrenics have led to contradictory interpretations of the importance of DMPEA in urine as an indicator of schizophrenia....
Demethylation of psychotomimetic compounds was measured by labeling each methyl and methoxy substitutent separately with 14C and injecting it into rats, intravenously and intracerebrally. Expired [14C]CO2 was measured continuously and the resultant multi-exponential curves yielded rates and integral demethylation. 5-Methoxy-N,N-dimethyltryptamine was not demethylated, eliminating one proposed...
AbstractA rapid and convenient synthesis of the psychotomimetic agent 4‐iodo‐2, 5‐dimethoxyphenylisopropylamine is described, incorporating the radioisotope 123I (T1/2 13 hr). With the amine function of 2, 5‐dimethoxyphenylisopropylamine blocked as the phthalimide, it was found that the aromatic 4‐position could be directly iodinated with iodine monochloride. The phthalic acid moiety was...