Cerebral and peripheral demethylation of psychotomimetics measured by expired 14CO2.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1989 Thornton W. Sargent, U Braun, Gisela Braun et al. 2 citations
Demethylation of psychotomimetic compounds was measured by labeling each methyl and methoxy substitutent separately with 14C and injecting it into rats, intravenously and intracerebrally. Expired [14C]CO2 was measured continuously and the resultant multi-exponential curves yielded rates and integral demethylation. 5-Methoxy-N,N-dimethyltryptamine was not demethylated, eliminating one proposed...