Retigabine promotes ketamine's antidepressant effect in the forced swim test in male and female C57BL/6J mice.
Pharmacology, biochemistry, and behavior September 1, 2023 Yixue Qin, Haoxuan Li, Yuqi Zhang et al. 6 citations
Ketamine has been increasingly used as a rapid-onset antidepressant in specific clinical settings. However, as a psychedelic reagent, the potential of physical and psychological dependence limits its clinical use. Here, we added retigabine, a KCNQ channel opener, as an adjunctive treatment to observe its effect on ketamine's antidepressant property in a forced swim test in both male and female...