Chronic pain and psychedelics: a review and proposed mechanism of action
Regional Anesthesia & Pain Medicine May 4, 2020 Joel Castellanos, C. Leonard Woolley, Kelly Bruno et al. 118 citations
The development of chronic pain is a complex mechanism that is still not fully understood. Multiple somatic and visceral afferent pain signals, when experienced over time, cause a strengthening of certain neural circuitry through peripheral and central sensitization, resulting in the physical and emotional perceptual chronic pain experience. The mind-altering qualities of psychedelics have been...