Continuous flow synthesis of N,N-dimethyltryptamine (DMT) analogues with therapeutic potential.
RSC Medicinal Chemistry October 7, 2024 Andreas Simoens, Andreas Dejaegere, Marthe Vandevelde et al. 2 citations
A continuous flow chemistry method was developed to synthesize N,N-dimethyltryptamine (DMT) and several of its analogues via a Fischer indole reaction, enabling a gram-scale production of 4.75 g of a model compound. The products were converted into stable fumarate salts for easy handling and long-term storage. The same setup also produced the commercial drug rizatriptan benzoate with high purity. The synthesis and purification used relatively green solvents, reducing environmental impact. This approach offers a scalable, efficient route for manufacturing DMT and related compounds for potential therapeutic applications.