Psycho-Oncology
July 1, 2025
Hongdao Meng, Cecile A Lengacher, Rio Tate et al.
1 citation
To conduct an economic evaluation of a group mindfulness program compared to an education support program for breast cancer survivors (BCS). The cost-utility analysis (cost per quality-adjusted life year [QALY]) was performed from a single-center randomized controlled trial in the United States. Data from 181 BCS were included in the analysis (91 from the mindfulness-based stress reduction for...
Journal of Integrative and Complementary Medicine
April 1, 2025
Cecile A Lengacher, Gizem Hueluer, Julia R. Wang et al.
Introduction: The Mindfulness-Based Stress Reduction program for breast cancer survivors (MBSR [BCs]) is a stress-reducing program designed to increase cognitive functioning through four meditational practices. This randomized clinical trial aimed to determine if improvements in cognitive functioning and perceived cognitive abilities achieved from the MBSR(BC) were mediated through increased...
Translational Behavioral Medicine
August 20, 2018
Jong Y Park, Cecile A Lengacher, R. Reich et al.
Genetic variations of breast cancer survivors (BCS) may contribute to level of residual symptoms, such as depression, stress, fatigue, and cognitive impairment. The objective of this study was to investigate whether particular single-nucleotide polymorphisms (SNPs) moderated symptom improvement resulting from the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR[BC]) program. An...
Biological Research for Nursing
August 5, 2018
Cecile A Lengacher, R. Reich, Carly L Paterson et al.
Breast cancer survivors (BCS) often experience psychological and physiological symptoms after cancer treatment. Mindfulness-based stress reduction (MBSR), a complementary and alternative therapy, has reduced subjective measures of stress, anxiety, and fatigue among BCS. Little is known, however, about how MBSR affects objective markers of stress, specifically the stress hormone cortisol and the...
Psycho-Oncology
February 1, 2018
Cecile A Lengacher, Richard R Reich, Sophia Ramesar et al.
The purpose of this pilot study was to test the feasibility of delivering the mobile mindfulness-based stress reduction for breast cancer (mMBSR(BC)) program using an iPad and to evaluate its impact on symptom improvement. A single group, pre-posttest design was implemented among female stages 0-III breast cancer survivors (BCS) who completed treatment. Data were collected at baseline and week...
Biological Research for Nursing
July 2017
Richard R Reich, Cecile A Lengacher, Thomas W. Klein et al.
The purpose of this substudy of a large randomized controlled trial was to evaluate the efficacy of the Mindfulness-Based Stress Reduction (Breast Cancer) (MBSR[BC]) program compared to usual care (UC) in normalizing blood levels of pro-inflammatory cytokines among breast cancer survivors (BCS). A total of 322 BCS were randomized to either a 6-week MBSR(BC) program or a UC. At baseline and 6...
Journal of Pain and Symptom Management
January 2017
Richard R Reich, Cecile A Lengacher, Carissa B Alinat et al.
Breast cancer survivors (BCS) face adverse physical and psychological symptoms, often co-occurring. Biologic and psychological factors may link symptoms within clusters, distinguishable by prevalence and/or severity. Few studies have examined the effects of behavioral interventions or treatment of symptom clusters. The aim of this study was to identify symptom clusters among post-treatment BCS...
Journal of Clinical Oncology
August 20, 2016
Cecile A Lengacher, Richard R Reich, Carly L Paterson et al.
The purpose of this randomized trial was to evaluate the efficacy of the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR[BC]) program in improving psychological and physical symptoms and quality of life among breast cancer survivors (BCSs) who completed treatment. Outcomes were assessed immediately after 6 weeks of MBSR(BC) training and 6 weeks later to test efficacy over an extended...
Psycho-Oncology
June 18, 2014
Cecile A Lengacher, R. Reich, C. Paterson et al.
The purpose of this study was to investigate the effects of mindfulness‐based stress reduction for breast cancer survivors (MBSR(BC)) on multiple measures of objective and subjective sleep parameters among breast cancer survivors (BCS).
Biological Research for Nursing
January 30, 2014
Cecile A Lengacher, R. Reich, Kevin E Kip et al.
Mindfulness-based stress reduction (MBSR) reduces symptoms of depression, anxiety, and fear of recurrence among breast cancer (BC) survivors. However, the effects of MBSR (BC) on telomere length (TL) and telomerase activity (TA), known markers of cellular aging, psychological stress, and disease risk, are not known. This randomized, wait-listed, controlled study, nested within a larger trial,...
Cecile A Lengacher, L. Forest Gruss, Kevin E Kip et al.
preprint
ABSTRACT: MBSR(BC) is known to have a positive impact on psychological and physical symptoms among breast cancer survivors (BCS). However, the cognitive mechanisms of “how” MBSR(BC) works are unknown. The purpose of this study, as part of a larger R01 trial, was to test whether positive effects achieved from the MBSR(BC) program were mediated through changes in increased mindfulness, decreased...