Biological Research for Nursing
July 2017
Richard R Reich, Cecile A Lengacher, Thomas W. Klein et al.
The purpose of this substudy of a large randomized controlled trial was to evaluate the efficacy of the Mindfulness-Based Stress Reduction (Breast Cancer) (MBSR[BC]) program compared to usual care (UC) in normalizing blood levels of pro-inflammatory cytokines among breast cancer survivors (BCS). A total of 322 BCS were randomized to either a 6-week MBSR(BC) program or a UC. At baseline and 6...
Journal of Pain and Symptom Management
January 2017
Richard R Reich, Cecile A Lengacher, Carissa B Alinat et al.
Breast cancer survivors (BCS) face adverse physical and psychological symptoms, often co-occurring. Biologic and psychological factors may link symptoms within clusters, distinguishable by prevalence and/or severity. Few studies have examined the effects of behavioral interventions or treatment of symptom clusters. The aim of this study was to identify symptom clusters among post-treatment BCS...
Journal of Clinical Oncology
August 20, 2016
Cecile A Lengacher, Richard R Reich, Carly L Paterson et al.
The purpose of this randomized trial was to evaluate the efficacy of the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR[BC]) program in improving psychological and physical symptoms and quality of life among breast cancer survivors (BCSs) who completed treatment. Outcomes were assessed immediately after 6 weeks of MBSR(BC) training and 6 weeks later to test efficacy over an extended...
Biological Research for Nursing
2013
Cecile A Lengacher, Kevin E Kip, Janice Post-White et al.
Objectives: This randomized controlled trial was conducted to examine immune recovery following breast cancer (BC) therapy and evaluate the effect of mindfulness-based stress reduction therapy (MBSR) on immune recovery with emphasis on lymphocyte subsets, T cell activation, and production of T-helper 1 (Th1; interferon [IFN]-γ) and T-helper 2 (Th2; interleukin-4 [IL-4]) cytokines. Method:...
Journal of Holistic Nursing
June 2011
Cecile A Lengacher, Versie Johnson-Mallard, Michelle Barta et al.
To assess the feasibility of whether mindfulness-based stress reduction (MBSR) has a positive effect on breast cancer survivors' psychological status, psychosocial characteristics, symptoms, and quality of life (QOL) during the critical transition period from end of treatment to resumption of daily activities. Single-group, quasi-experimental, pretest-posttest design. A sample of 19 women who...
Psycho-Oncology
December 2009
Cecile A Lengacher, Versie Johnson-Mallard, Janice Post-White et al.
Considerable morbidity persists among survivors of breast cancer (BC) including high levels of psychological stress, anxiety, depression, fear of recurrence, and physical symptoms including pain, fatigue, and sleep disturbances, and impaired quality of life. Effective interventions are needed during this difficult transitional period. We conducted a randomized controlled trial of 84 female BC...
Journal of General Internal Medicine
December 2005
Margaret Plews-Ogan, Justine E Owens, Matthew Goodman et al.
Mindfulness-based stress reduction (MBSR) and massage may be useful adjunctive therapies for chronic musculoskeletal pain. To evaluate the feasibility of studying MBSR and massage for the management of chronic pain and estimate their effects on pain and mood. Randomized trial comparing MBSR or massage with standard care. Thirty patients with chronic musculoskeletal pain. Pain was assessed with...
Cecile A Lengacher, L. Forest Gruss, Kevin E Kip et al.
preprint
ABSTRACT: MBSR(BC) is known to have a positive impact on psychological and physical symptoms among breast cancer survivors (BCS). However, the cognitive mechanisms of “how” MBSR(BC) works are unknown. The purpose of this study, as part of a larger R01 trial, was to test whether positive effects achieved from the MBSR(BC) program were mediated through changes in increased mindfulness, decreased...