Journal of AOAC International
August 13, 2025
Kimberley Foster, Isaac Morrison, S. Daniel et al.
4 citations
Abstract Background The consumption of dried fruiting bodies of Psilocybe cubensis can be traced over centuries, guided by Mesoamerican curanderas, Western medical practitioners, and fungal enthusiasts, all seeking mental wellbeing. There is a notable resurgence in interest both in the fungal biomass and psilocybin, the psychoactive tryptamine, despite the global regulatory restrictions,...
Microbiology Resource Announcements
December 27, 2024
Harte Singer, Jordan Jacobs, Marshall Tyler et al.
3 citations
ABSTRACT Psilocybe is a genus of mushroom-forming fungi with ecological, ethnomycological, and clinical importance due to psilocybin production by most species. We present five genomes that enable deeper discovery and analysis of the psilocybin gene cluster and increase taxonomic resolution within Psilocybe : Psilocybe semilanceata , Psilocybe gandalfiana nom. prov., Psilocybe caeruleorhiza ,...
Fungal biology
February 1, 2024
Kimberley Foster, Isaac Morrison, Marshall Tyler et al.
3 citations
Psychedelic fungi have experienced a surge in interest in recent years. Most notably, the fungal secondary metabolite psilocybin has shown tremendous promise in the treatment of various psychiatric disorders. The mushroom species that produce this molecule are poorly understood. Here we sought to examine for the first time, the response of a psilocybin-producing species Psilocybe cubensis to...
Computational biology and chemistry
June 1, 2023
William Irvine, Marshall Tyler, Rupika Delgoda
11 citations
Nearly all mushrooms of the Psilocybe genus contain the natural product psilocybin, which is a psychoactive alkaloid derived from l-tryptophan. Considering their use in ancient times, as well as their psychedelic properties, these mushrooms have re-emerged with psychotherapeutic potential for treating depression, which has triggered increased pharmaceutical interest. However, the psilocybin...