Stratification of unresponsive patients by an independently validated index of brain complexity
Annals of Neurology September 22, 2016 Silvia Casarotto, Angela Comanducci, Mario Rosanova et al. 504 citations
OBJECTIVE: Validating objective, brain-based indices of consciousness in behaviorally unresponsive patients represents a challenge due to the impossibility of obtaining independent evidence through subjective reports. Here we address this problem by first validating a promising metric of consciousness-the Perturbational Complexity Index (PCI)-in a benchmark population who could confirm the...