iScience
January 17, 2025
Paolo Cardone, Arthur Bonhomme, Vincent Bonhomme et al.
9 citations
Post-comatose disorders of consciousness (DoC) represent persistent neurological conditions with limited therapeutic options and a poor prognosis. Recent works advocate for exploring the effects of psychedelics to enhance brain complexity in DoC and ameliorate their consciousness. We investigated sub-anesthetic concentration of the atypical psychedelic ketamine for treating post-comatose...
BJA Open
September 26, 2023
Javier Montupil, Paolo Cardone, Cécile Staquet et al.
32 citations
Neuroscientists agree on the value of locating the source of consciousness within the brain. Anaesthesiologists are no exception, and have their own operational definition of consciousness based on phenomenological observations during anaesthesia. The full functional correlates of consciousness are yet to be precisely identified, however rapidly evolving progress in this scientific domain has...
Frontiers in Systems Neuroscience
August 14, 2019
Vincent Bonhomme, Cécile Staquet, Javier Montupil et al.
109 citations
General anesthesia reversibly alters consciousness, without shutting down the brain globally. Depending on the anesthetic agent and dose, it may produce different consciousness states including a complete absence of subjective experience (unconsciousness), a conscious experience without perception of the environment (disconnected consciousness, like during dreaming), or episodes of oriented...
Functional MRI
December 1, 2018
Nasim Mortazavi, Cécile Staquet, Audrey Vanhaudenhuyse et al.
This chapter reviews current knowledge of the effects of hypnotic anesthetic agents on brain resting-state networks (RSNs) that sustain consciousness. Although full exploration of the networks under anesthesia is not yet available, current evidence indicates that anesthetic agents with hypnotic properties dose-dependently modulate RSN functioning. Each anesthetic agent has specific effects that...