Neuroscience & Biobehavioral Reviews
June 1, 2025
Joshua Kugel, Ruben Laukkonen, David B. Yaden et al.
15 citations
Insight - a sudden change in understanding or perspective that feels true or reliable - is a common occurrence during psychedelic experiences, and often considered by clinicians and patients to be central to their therapeutic value. However, their occurrence and role has not been systematically assessed. We reviewed all peer-reviewed studies that published data on insight catalysed by a classic...
Cannabis and Cannabinoid Research
March 1, 2018
Nadia Solowij, Samantha J Broyd, Camilla Beale et al.
Introduction: Chronic cannabis use has been associated with impaired cognition and elevated psychological symptoms, particularly psychotic-like experiences. While Δ9-tetrahydrocannabinol (THC) is thought to be primarily responsible for these deleterious effects, cannabidiol (CBD) is purported to have antipsychotic properties and to ameliorate cognitive, symptomatic, and brain harms in cannabis...
Biological Psychiatry
April 1, 2016
Samantha J Broyd, Hendrika H Van Hell, Camilla Beale et al.
Cannabis use has been associated with impaired cognition during acute intoxication as well as in the unintoxicated state in long-term users. However, the evidence has been mixed and contested, and no systematic reviews of the literature on neuropsychological task-based measures of cognition have been conducted in an attempt to synthesize the findings. We systematically review the empirical...
Translational Psychiatry
January 12, 2016
Murat Yücel, Valentina Lorenzetti, Chao Suo et al.
Shifting policies towards legalisation of cannabis for therapeutic and recreational use raise significant ethical issues for health-care providers seeking evidence-based recommendations. We investigated whether heavy cannabis use is associated with persistent harms to the hippocampus, if exposure to cannabidiol offers protection, and whether recovery occurs with abstinence. To do this, we...
Current Pharmaceutical Design
2014
Valentina Lorenzetti, Nadia Solowij, Alex Fornito et al.
Cannabis is the most widely used illicit drug worldwide, though it is unclear whether its regular use is associated with persistent alterations in brain morphology. This review examines evidence from human structural neuroimaging investigations of regular cannabis users and focuses on achieving three main objectives. These include examining whether the literature to date provides evidence that...
Substance Use & Misuse
September 2010
Valentina Lorenzetti, Dan I Lubman, Sarah Whittle et al.
In animal studies, tetrahydrocannabinol (THC) has been found to affect brain morphology, particularly within areas rich in cannabinoid receptors (e.g., hippocampus, cerebral cortex). While cannabis remains the most widely used illicit drug worldwide, there has been limited work investigating its effects on human brain tissue. In this paper, we conducted a systematic review of existing...
Schizophrenia Bulletin
July 25, 2010
Murat Yücel, Emre Bora, Dan Ian Lubman et al.
256 citations
Cannabis use is highly prevalent among people with schizophrenia, and coupled with impaired cognition, is thought to heighten the risk of illness onset. However, while heavy cannabis use has been associated with cognitive deficits in long-term users, studies among patients with schizophrenia have been contradictory. This article consists of 2 studies. In Study I, a meta-analysis of 10 studies...
Proceedings of the National Academy of Sciences
July 15, 2008
Ben J. Harrison, Jesus Pujol, Marina López-solà et al.
The notion of a “default mode of brain function” has taken on certain relevance in human neuroimaging studies and in relation to a network of lateral parietal and midline cortical regions that show prominent activity fluctuations during passive imaging states, such as rest. In this study, we perform three fMRI experiments that demonstrate consistency and specialization in the default mode...