Mechanisms of action of ibogaine and harmaline congeners based on radioligand binding studies.
Brain Research February 7, 1992 D C Deecher, M Teitler, D M Soderlund et al. 143 citations
Assays using radioligands were used to assess the actions of ibogaine and harmaline on various receptor types. Ibogaine congeners showed affinity for opiate receptors whereas harmaline and harmine did not. The Ki for coronaridine was 2.0 microM at mu-opiate receptors. The Kis for coronaridine and tabernanthine at the delta-opiate receptors were 8.1 and 3.1 microM, respectively. Ibogaine,...