Excitotoxic insult due to ibogaine leads to delayed induction of neuronal NOS in Purkinje cells.
Neuroreport August 21, 1995 E O'Hearn, P Zhang, M E Molliver 77 citations
Ibogaine causes degeneration of Purkinje cells (PKCs), presumably via activation of neurons in the inferior olive leading to release of glutamate at climbing fiber terminals. Following ibogaine administration, some Purkinje cells express NADPH-diaphorase and neuronal NOS (nNOS), neither of which is present normally in these cells. The induction of NOS is delayed in onset, dose-related, and...