Acute and chronic administration of ibogaine to the rat results in astrogliosis that is not confined to the cerebellar vermis.
Annals of the New York Academy of Sciences October 31, 1996 J P O'Callaghan, T S Rogers, L E Rodman et al. 14 citations
Acute administration of high doses of ibogaine (IBG) to the male rat results in degeneration of Purkinje cells and reactive gliosis in the cerebellar vermis. We examined whether acute and chronic administration of IBG to male and female rats results in gliosis as determined by quantification of the astroglial intermediate filament protein, glial fibrillary acidic protein (GFAP). After acute...