Acute and chronic administration of ibogaine to the rat results in astrogliosis that is not confined to the cerebellar vermis.
J P O'Callaghan, T S Rogers, L E Rodman, J G Page
Annals of the New York Academy of Sciences October 31, 1996 DOI: 10.1111/j.1749-6632.1996.tb17443.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Male and female rats |
| Intervention | ibogaine |
| Duration | Acute and chronic administration |
| Topics | Ibogaine |
| Citations | 14 |
| Key findings | Ibogaine administration causes dose- and sex-dependent gliosis and damage in multiple brain regions outside the cerebellum, with chronic treatment affecting females more than males. |
Abstract
Acute administration of high doses of ibogaine (IBG) to the male rat results in degeneration of Purkinje cells and reactive gliosis in the cerebellar vermis. We examined whether acute and chronic administration of IBG to male and female rats results in gliosis as determined by quantification of the astroglial intermediate filament protein, glial fibrillary acidic protein (GFAP). After acute administration of IBG, rats of both sexes showed dose-related increases in GFAP that were not confined to the cerebellar vermis. After chronic administration of IBG, female, but not male rats, showed large (as much as 200% of control), dose-related increases in GFAP in hippocampus, olfactory bulbs, brain stem and striatum, but not cerebellum. In hippocampus, the cytoskeletal proteins, neurofilament 68 (NF-68) and beta-tubulin were increased in females treated chronically with IBG, findings consistent with a damage-induced sprouting response. Together, the data indicate that IBG damages areas of the brain outside the cerebellum and that the sites damaged are dependent on sex and dosage regimen.
Comparable studies
Other preclinical and animal studies on ibogaine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Noncompetitive Functional Inhibition at Diverse, Human Nicotinic Acetylcholine Receptor Subtypes by Bupropion, Phencyclidine, and Ibogaine TE671/RD cells (human muscle-type nAChR) and SH-SY5Y neuroblastoma cells (human... | 1999 | In vitro study | |
| Degeneration of Purkinje cells in parasagittal zones of the cerebellar vermis after treatment with ibogaine or harmaline. Ibogaine- or harmaline-treated rats | 1993 | Experimental animal study | |
| Effects and aftereffects of ibogaine on morphine self-administration in rats. Rats | 1991 | Preclinical experimental study | |
| Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Rats | 1994 | Experimental study | |
| Glial Cell Line-Derived Neurotrophic Factor Mediates the Desirable Actions of the Anti-Addiction Drug Ibogaine against Alcohol Consumption Rats | 2005 | Experimental study |
Citations in the library
Cited by 4
- A dose-response study of ibogaine-induced neuropathology in the rat cerebellum. Toxicological sciences : an official journal of the Society of Toxicology September 1, 2000
- Ibogaine and Noribogaine: Comparing Parent Compound to Metabolite CNS Drug Reviews September 1, 2000
- Ibogaine alters synaptosomal and glial glutamate release and uptake. Neuroreport February 12, 2001
- Neurochemical and Neuroendocrine Effects of Ibogaine in Rats: Comparison to MK-801. Annals of the New York Academy of Sciences May 1, 1998
Cites 5
- Degeneration of Purkinje cells in parasagittal zones of the cerebellar vermis after treatment with ibogaine or harmaline. Neuroscience July 1, 1993
- Effects of ibogaine on acute signs of morphine withdrawal in rats: independence from tremor. Neuropharmacology May 1, 1992
- Ibogaine induces glial activation in parasagittal zones of the cerebellum. Neuroreport March 1, 1993
- The use of toxicokinetics for the safety assessment of drugs acting in the brain. Molecular Neurobiology 1995
- Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse. Journal of Pharmacology and Experimental Therapeutics August 1, 1994