Ibogaine block of the NMDA receptor: in vitro and in vivo studies.
Neuropharmacology April 1, 1996 K Chen, T G Kokate, S D Donevan et al. 55 citations
Ibogaine is an hallucinogenic indole alkaloid claimed to have anti-addictive properties. Although its mechanism of action is unknown, binding studies have indicated that the drug may interact with N-methyl-D-aspartate (NMDA) receptors. We further investigated the nature of the interaction between ibogaine and NMDA receptors in voltage clamp and binding studies, and sought to confirm that the...