Natural products from the hallucinogenic sage.
Science progress January 1, 2010 James R Hanson 10 citations
This review describes the isolation, chemical structures, and biological activity of neoclerodane and other natural products from the Mexican hallucinogenic sage, Salvia divinorum. It covers the plant's secondary metabolites, particularly neoclerodane diterpenes, and their pharmacological properties, including interactions with opioid receptors and other targets relevant to medicinal chemistry and drug discovery. The review consolidates findings on compound isolation, structural elucidation, and bioactivity, highlighting the potential of these natural products for developing new therapeutic agents.