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Avraham Rosenberg

2 papers in the library · 29 citations · publishing 2010

Papers

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Interaction of ibogaine with human alpha3beta4-nicotinic acetylcholine receptors in different conformational states.

The international journal of biochemistry & cell biology September 1, 2010 Hugo R Arias, Avraham Rosenberg, Katarzyna M Targowska-Duda et al. 29 citations

The interaction of ibogaine and phencyclidine (PCP) with human (h) alpha3beta4-nicotinic acetylcholine receptors (AChRs) in different conformational states was determined by functional and structural approaches including, radioligand binding assays, Ca2+ influx detections, and thermodynamic and kinetics measurements. The results established that (a) ibogaine inhibits (+/-)-epibatidine-induced...

DOI: 10.1016/j.biocel.2010.05.011 (opens in new tab) Full text (opens in new tab) Ibogaine: ibogaine Human brain receptor Key brain receptors Receptor's channel +9

Interaction of 18-methoxycoronaridine with nicotinic acetylcholine receptors in different conformational states.

Biochimica et biophysica acta June 2010 Hugo R Arias, Avraham Rosenberg, Dominik Feuerbach et al.

The interaction of 18-methoxycoronaridine (18-MC) with nicotinic acetylcholine receptors (AChRs) was compared with that for ibogaine and phencyclidine (PCP). The results established that 18-MC: (a) is more potent than ibogaine and PCP inhibiting (+/-)-epibatidine-induced AChR Ca(2+) influx. The potency of 18-MC is increased after longer pre-incubation periods, which is in agreement with the...

DOI: 10.1016/j.bbamem.2010.03.013 (opens in new tab) Full text (opens in new tab)