Interaction of ibogaine with human a3b4 nicotinic receptors in different conformational states
The FASEB Journal April 1, 2012 Ilana Emert, Katarzyna M Targowska-Duda, Dominik Feuerbach et al.
The interaction of ibogaine and phencyclidine (PCP) with human (h) α3β4 nicotinic acetylcholine receptors (AChRs) in different conformational states was determined using radioligand binding assays, Ca 2+ influx detections, thermodynamic and kinetic measurements. The results show that ibogaine inhibits (±)‐epibatidine‐induced Ca 2+ influx in hα3β4 AChRs with ~9‐fold higher potency than PCP, [ 3...