Learning and memory impairment induced by salvinorin A, the principal ingredient of Salvia divinorum, in wistar rats.
International journal of toxicology December 1, 2011 Daniela Braida, Andrea Donzelli, Roberta Martucci et al. 29 citations
The effects of salvinorin A (Salvia divinorum principal ingredient), a potent κ-opioid natural hallucinogen, on learning and memory were investigated. Wistar rats were tested in the 8-arm radial maze, for object recognition and passive avoidance tasks for spatial, episodic, and aversive memory. Attention was assessed using a latent inhibition task. Salvinorin A (80-640 μg/kg subcutaneous [sc])...