A unique natural selective kappa-opioid receptor agonist, salvinorin A, and its roles in human therapeutics.
Phytochemistry May 1, 2017 André Cruz, Sara Domingos, Eugenia Gallardo et al. 44 citations
Until the mid-60s, only the Mazatecs, an indigenous group from Oaxaca, Mexico, used Salvia Divinorum (S. divinorum) due to its hallucinogen properties. Later it was found that the hallucinogen effects of this plant were caused by the presence of a neoclerodane diterpene Salvinorin A (salvinorin A), which is a highly selective agonist of kappa-opioid receptor (KOR) that cause more intense...