Alzheimer's disease causes severe cognitive decline and lacks effective treatments to halt neurodegeneration or promote neuronal repair. Psychoactive substances, including central nervous system depressants and stimulants, cannabinoids, psychedelics, opioids, and ketamine, are being explored for their abilities to enhance learning and cognitive performance and potential neurorestorative functions. This review examines the molecular mechanisms and therapeutic potential of these compounds in Alzheimer's disease, aiming to guide future research directions.
Childhood adversity is associated with the content of adult dreams, specifically the characters, friendly interactions, and objects that appear in them. In a cross-sectional study of 120 healthy adults aged 18–35 who recorded dreams for 10 consecutive days, those who reported more childhood trauma also showed differences in dream elements, as coded by the Hall and Van de Castle system. Regression models predicted dream characters and objects from childhood adversity scores. No gender differences were found in dream recall, sleep quality, emotional state, or childhood adversity levels.