In prodromal and early schizophrenia, disorders of attention and perception are associated with structural and chemical brain abnormalities, and with dysfunctional corticothalamic networks exhibiting disturbed brain rhythms. The underlying mechanisms are elusive. The non-competitive NMDA receptor antagonist ketamine simulates the symptoms of prodromal and early schizophrenia, including...
Hyperthermia is a key clinical outcome from recreational use of MDMA and is the leading cause of MDMA related hospital admissions as well as being linked to enhanced neurotoxicity [1, 2]. Animal models of ischemia which also display hyperthermia have shown an inflammatory process mediated by microglia and the release of the proinflammatory cytokine interleukin 1(IL-1 ) play a role in...