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Terence J. O'Brien

2 papers in the library · publishing 2026

Papers

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Psilocybin restores behavior and 5-HT2A signaling while reducing microglial density after chronic traumatic brain injury in rats.

Cell reports. Medicine June 12, 2026 Josh Allen, Bianca Jupp, Tamara L Baker et al.

Traumatic brain injury (TBI) causes persistent neurobehavioral deficits and increases the risk of psychiatric disorders, including depression, anxiety, and cognitive dysfunction linked to disrupted neuroplasticity, neuroinflammation, and serotonergic (5-HT) signaling. No effective pharmacotherapies exist for chronic TBI. Psilocybin, a psychedelic 5-HT2A receptor agonist, shows promise due to...

The therapeutic effect of breathing interventions for functional seizures: A scoping review.

Epilepsy & Behavior February 23, 2026 Jade-Jocelyne Zouki, Hua Ye, Alfred Pak-Kwan Lo et al.

Functional/Dissociative Seizures (FDS) are presentations that appear like epileptic seizures but occur without abnormal cortical electrical activity in the brain. Abnormal respiratory patterns, particularly hyperventilation, have been frequently observed in people with FDS, suggesting this may be a potential therapeutic target. This scoping review aimed to explore the various applications of...