The psychotomimetic ketamine disrupts the transfer of late sensory information in the corticothalamic network
bioRxiv Preprint Server February 21, 2022 Yi Qin, Ali Mahdavi, Marine Bertschy et al. preprint
In prodromal and early schizophrenia, disorders of attention and perception are associated with structural and chemical brain abnormalities, and with dysfunctional corticothalamic networks exhibiting disturbed brain rhythms. The underlying mechanisms are elusive. The non-competitive NMDA receptor antagonist ketamine simulates the symptoms of prodromal and early schizophrenia, including...