Modulation of amphetamine-induced striatal dopamine release by ketamine in humans: implications for schizophrenia.
Biological Psychiatry October 1, 2000 Lawrence S. Kegeles, Anissa Abi‐dargham, Y. Zea‐Ponce et al.
BACKGROUND Recent brain imaging studies have indicated that schizophrenia is associated with increased amphetamine-induced dopamine release in the striatum. It has long been hypothesized that dysregulation of subcortical dopamine systems in schizophrenia might result from a failure of the prefrontal cortex (PFC) to adequately control subcortical dopaminergic function. The activity of midbrain...