Yushan Luo

Targeting NMDAR2A in microglia: esketamine suppresses M1 polarization in BV2 cells.

Molecular Biology Reports October 22, 2026 Hui Li, Xiaoyuan Zhang, Yushan Luo et al.

Objective: Microglial polarization toward the M1 phenotype is a key contributor to the initiation and progression of neuroinflammatory diseases, primarily through the release of pro-inflammatory cytokines that exacerbate central nervous system-associated injury. Activation of N-methyl-D-aspartic acid receptors (NMDARs) is implicated in microglial overactivation and cytotoxicity. This study...