Molecular basis of the selective binding of MDMA enantiomers to the alpha4beta2 nicotinic receptor subtype: synthesis, pharmacological evaluation and mechanistic studies.
European journal of medicinal chemistry June 23, 2014 Salomé Llabrés, Sara Garcia-Ratés, Edgar Cristóbal-Lecina et al.
The α4β2 nicotinic acetylcholine receptor (nAChR) is a molecular target of 3,4-methylenedioxymethamphetamine (MDMA), a synthetic drug also known as ecstasy, and it modulates the MDMA-mediated reinforcing properties. However, the enantioselective preference of the α4β2 nAChR subtype still remains unknown. Since the two enantiomers exhibit different pharmacological profiles and stereoselective...
DOI: 10.1016/j.ejmech.2014.04.044 (opens in new tab)
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MDMA
Alpha4beta2 nicotinic receptor
Enantioselective binding
Molecular modelling
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