Effects of Δ9-THC and Type-1 Cannabinoid Receptor Agonists in the Elevated Plus Maze Test of Anxiety: A Systematic Review and Meta-Analysis.
Cannabis and Cannabinoid Research February 2023 Lia P Iglesias, Lucas Bedeschi, Daniele C Aguiar et al.
Δ9-THC (the main active compound from Cannabis sativa) and related cannabinoids have been used as drugs of abuse and as medications. They induce a complex set of emotional responses in humans and experimental animals, consisting of either anxiolysis or heightened anxiety. These discrepant effects pose a major challenge for data reproducibility and for developing new cannabinoid-based medicines....
DOI: 10.1089/can.2022.0078 (opens in new tab)
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Anxiety
Cb1 receptor
Animal models
Anxiolytics
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