Laila Asth

2 papers in the library · publishing 2018-2023

Papers

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Effects of Δ9-THC and Type-1 Cannabinoid Receptor Agonists in the Elevated Plus Maze Test of Anxiety: A Systematic Review and Meta-Analysis.

Cannabis and Cannabinoid Research February 2023 Lia P Iglesias, Lucas Bedeschi, Daniele C Aguiar et al.

Δ9-THC (the main active compound from Cannabis sativa) and related cannabinoids have been used as drugs of abuse and as medications. They induce a complex set of emotional responses in humans and experimental animals, consisting of either anxiolysis or heightened anxiety. These discrepant effects pose a major challenge for data reproducibility and for developing new cannabinoid-based medicines....

DOI: 10.1089/can.2022.0078 Full text Anxiety Cb1 receptor Animal models Anxiolytics +2

NOP agonists prevent the antidepressant-like effects of nortriptyline and fluoxetine but not R-ketamine.

Psychopharmacology November 2018 Victor A D Holanda, Wilton B Santos, Laila Asth et al.

Nociceptin/orphanin FQ (N/OFQ) is the endogenous ligand of a Gi protein-coupled receptor named NOP. Both N/OFQ and NOP receptor are widely expressed in brain areas involved in the control of emotional processes. Clinical and preclinical studies support antidepressant effects due to the blockade of NOP receptor signaling. By contrast, NOP receptor activation did not evoke any change in...

DOI: 10.1007/s00213-018-5004-7 Full text Antidepressants Forced swimming test Learned helplessness Mouse +2