Yoshihiro Oyamada

2 papers in the library · publishing 2014-2016

Papers

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Subchronic phencyclidine treatment in adult mice increases GABAergic transmission and LTP threshold in the hippocampus.

Neuropharmacology January 2016 Toshihiro Nomura, Yoshihiro Oyamada, Herman B Fernandes et al.

Repeated administration of non-competitive N-methyl-d-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP) to rodents causes long-lasting deficits in cognition and memory, and has effects on behaviors that have been suggested to be models of the cognitive impairment associated with schizophrenia (CIAS). Despite this being a widely studied animal model, little is known about the...

DOI: 10.1016/j.neuropharm.2015.04.012 Full text Gaba Hippocampus Inhibitory postsynaptic current Long-term potentiation +1

The novel object recognition test in rodents in relation to cognitive impairment in schizophrenia.

Current Pharmaceutical Design 2014 Lakshmi Rajagopal, Bill W Massey, Mei Huang et al.

Novel object recognition (NOR) in rodents is analogous in some ways to human declarative (episodic) memory, one of the seven cognitive domains which are abnormal in schizophrenia. Cognitive impairment in schizophrenia (CIS) accounts for the largest proportion of the poor functional outcomes in this complex syndrome, with psychosis and negative symptoms accounting for much of the rest. Current...

DOI: 10.2174/1381612819666131216114240 Full text