The role of serotonin in the NMDA receptor antagonist models of psychosis and cognitive impairment.
Psychopharmacology February 1, 2011 Herbert Y. Meltzer, Masakuni Horiguchi, Bill W Massey
To review the evidence that agents which preferentially affect serotonin (5-HT) attenuate the ability of N-methyl-D-aspartate (NMDA) receptor non-competitive antagonists (NMDA-RA), e.g., phencyclidine (PCP), dizocilpine (MK-801), and ketamine, to stimulate locomotor activity (LA), and to impair novel object recognition (NOR). NMDA-RA-induced increased LA and impairment of NOR are widely used...