medRxivJuly 10, 2026Daniel Copeland, Naoise Mac Giollabhui, Louisa G Sylvia et al.
preprint
Background: Despite growing evidence that lifestyle interventions reduce depressive symptoms, the psychological mechanisms underlying these effects remain poorly understood. This study examined whether mindfulness and rumination mediate the antidepressant effects of heated yoga (HY), a multicomponent intervention combining physical activity, attentional training, and thermoregulatory stress....
BACKGROUND Several studies indicate that ketamine has rapid antidepressant effects in patients with treatment-resistant depression (TRD). The extent to which repeated doses of ketamine (versus placebo) reduce depression in the short and long term among outpatients with TRD and chronic, current suicidal ideation remains unknown. METHODS Twenty-six medicated outpatients with severe major...