Ascorbic acid enhances antidepressant-like efficacy of esketamine: Hippocampal TARP-γ8-containing AMPA receptors mediate synaptic modulation.
Neurotherapeutics November 11, 2025 Zhaojuan Ke, Ying Zhang, Xin Jiang et al.
Ketamine exhibits superior efficacy compared to conventional antidepressants, yet its clinical application remains limited by dose-dependent side effects. Ascorbic acid (AA) augments ketamine's antidepressant-like effects, suggesting that AA co-administration with subtherapeutic ketamine doses may achieve optimal efficacy while improving safety. Since AA itself lacks independently clinical...
DOI: 10.1016/j.neurot.2025.e00786 (opens in new tab)
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Ketamine
Depression
Hippocampus
Synapses
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