Esketamine ameliorates post-stroke anxiety by modulating microglial HDAC3/NF-κB/COX1 inflammatory signaling in ischemic cortex.
European Journal of Pharmacology March 28, 2023 Ailing Huang, Yang Chen, Shaoshuang Wang et al.
Post-stroke anxiety (PSA) is a kind of affective disorder occurring after a stroke, with anxiety as the primary clinical manifestation. PSA's mechanism is unclear, and there are few prevention and treatment measures. Our previous study found that HDAC3 could activate NF-κB signaling through mediated p65 deacetylation, which further influenced microglia activation. That implies HDAC3 may be the...
DOI: 10.1016/j.ejphar.2023.175667 (opens in new tab)
Esketamine
Microglia
Animals
Mice, inbred c57bl
+6