Cells
August 1, 2025
Armida Miranda-Riestra, Rosa Estrada-Reyes, Luis A Constantino-Jonapa et al.
Forty per cent of major depression patients are resistant to antidepressant medication. Thus, it is necessary to search for alternative treatments. Melatonin (N-acetyl-5-hydroxytryptamine) enhances neurogenesis and neuronal survival in the adult mouse hippocampal dentate gyrus. Additionally, melatonin stimulates the activity of Ca2+/Calmodulin-dependent Kinase II (CaMKII), promoting dendrite...
Molecular Pharmacology
August 16, 2024
Armida Miranda-Riestra, Montserrat G Cercós, Citlali Trueta et al.
4 citations
Melatonin (N-acetyl-5-methoxytryptamine) is an indoleamine secreted by the pineal gland during the dark phase of the photoperiod. Its main function is the synchronization of different body rhythms with the dark-light cycle. Research on melatonin has significantly advanced since its discovery and we now know that it has considerable significance in various physiological processes, including...
Neuropharmacology
May 18, 2023
Gloria Benítez-King, Armida Miranda-Riestra, Rosa Estrada-Reyes et al.
ID
Molecules
September 1, 2022
Rosa Estrada-Reyes, Daniel B Quero-Chávez, Salvador Alarcón-Elizalde et al.
Melatonin (MEL), an indolamine with diverse functions in the brain, has been shown to produce antidepressant-like effects, presumably through stimulating neurogenesis. We recently showed that the combination of MEL with ketamine (KET), an NMDA receptor antagonist, has robust antidepressant-like effects in mice, at doses that, by themselves, are non-effective and have no adverse effects. Here,...
International Journal of Molecular Sciences
August 26, 2021
Rosa Estrada-Reyes, Daniel B Quero-Chávez, Citlali Trueta et al.
Major depressive disorder is a disabling disease with the number of affected individuals increasing each year. Current antidepressant treatments take between three to six weeks to be effective with forty percent of patients being resistant to treatment, making it necessary to search for new antidepressant treatments. Ketamine, a phencyclidine hydrochloride derivative, given intravenously,...