A 43-year-old woman experienced a psychotic episode two days after her third ayahuasca session in a ritual context. Symptoms included loss of consciousness, convulsions, weakness and numbness on the right side, and delusions of electromagnetic fields draining her life force. She required four days in intensive care, then was hospitalized and treated with risperidone 1.5 mg, leading to complete symptom remission. The case aligns with other reports of ayahuasca-induced psychosis, though with less intensity and duration. The rising use of ayahuasca in non-controlled and recreational settings warrants clinical awareness.
A combination of a non-effective dose of ketamine and melatonin (KET/MEL) increased neurogenesis and produced antidepressant-like effects in mice without altering locomotor activity, after both single and triple administration protocols. The authors strongly suggest that this combination could promote neurogenesis, revert neuronal atrophy, and induce antidepressant-like effects, potentially offering a treatment that avoids the psychomimetic side effects of ketamine alone.